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7-Keto DHEA is one of the three oxygenated metabolites that make up Dehydroepiandrosterone. Also known as 7-oxodehydroepiandrosterone, it is popularly known by its brand name, which is 7-keto.
Note that the three oxygenated metabolites in question can convert into each other but can’t change themselves to DHEA. That’s where 7-keto enters the picture, allowing access to these metabolites without having to use DHEA. (1)
7-keto is not hormonal in nature but can actively interact with the steroid metabolism. Furthermore, studies have found that it has anti-cortisol mechanisms (cortisol is a stress hormone).
Despite its anti-cortisol properties, there isn’t enough evidence that would support the mechanisms followed by an oral dose. It has been seen that 7-keto leads to a higher metabolic rate during a period of restricted calorie consumption.
According to some studies, 7-keto is a fat burning agent that is non hormonal in nature, however, a valid evidence is needed to back these claims.
7-Keto DHEA is also known as 7-oxoDHEA, 7-oxodehydroepiandrosterone, 7-oxo, 7-ketoDHEA, 7-ketodehydroepiandrosterone, and 7-keto. However, one should not confuse it with its parent molecule that goes by the name of Dehydroepiandrosterone.
Moreover, 7-keto supplementation is not androgenic or estrogenic in nature.
Health benefits of 7-Keto DHEA
7-Keto DHEA is a byproduct of DHEA that occurs naturally and is produced in the skin, adrenal gland, and the brain.
A lot of people don’t know this but there are almost 10 DHEA metabolites, and out of these, 7-keto is the most famous and valuable one. The component has a number of advantages.
It is seen that 7-Keto DHEA contributes to weight loss and can increase the metabolism in the body. The substance works by increasing the activity if the thermogenic enzymes that are known for the oxidation of fatty acids.
There are studies that show that the supplement has caused an increase of CoA oxidase by 128% and an increase of 860% when it comes to malic enzymes.
In a placebo controlled study conducted on thirty overweight people, the results showed a 2.1 pound decrease in the placebo compared to a massive 6.3 pound decease in the control group.
The only side effects that were recorded in this study were the elevation of the thyroid hormone. It is seen that when 7-keto is paired with exercise and diet, the results of fat loss were three times higher compared to not taking any other stimulant during weight loss.
Another health benefit of the 7-keto DHEA was that it showed an improvement in the immune function of the body.
A study was conducted on monkeys that were infected with simian HIV and the results showed an improved wellbeing, a notable increase in the T cells, and weight gain that can be accounted to the well being of the animals.
Other than this, a 4 week human trial was conducted on elderly men and women by the Minnesota Applied Research Center in order to see the effects of the 7-keto on the subjects. These elderly men and women were given one dose of 100 mg twice a day.
At the end of the trial, it was seen that the subjects has better immune health, decreased blood pressure, an increase in the white blood cell count, and an increase in the immune helper cells that contributed to t general well beings of the elderly participants.
Another benefit of the 7-Keto DHEA is that it acts as an anti-aging agent.
It is seen that 7-keto, being a natural metabolite of DHEA, declines with age in a way that is directly proportional to the parent hormone. The levels rise until the age of 20, and there is a decline in the blood concentration level by the age of 30. By the age of 50, there is almost a 50% reduction in the blood concentration level.
A study evaluated the effect of 7-keto on heart disease. A small dose of 25 mg per day for five days managed to increase the level of good cholesterol. The aggregate reduction of cholesterol was low but there was a huge difference in the atherogenic index, which is a measure used to study the risk of cardiovascular diseases in people.
There are other health benefits of 7-keto that involve improving the brain function, which is done by helping the neurons to come in contact with each other that stops brain aging.
According to Dr. Henry Lardy, a researcher in the field of 7-keto DHEA it is seen that the supplement only has benefits and no side effects. A 29-day trial was conducted on human beings and it was seen that there was no change in the urine chemistry, blood culture, and no conversion of the sex hormones of both the sexes. The subjects were given a dose of 200 mg of 7-keto and no side effects were observed in the results.
Safety and side effects
No side effects have been recorded for the 7-keto DHEA supplement.
A dosage of 7-Keto DHEA was given in two divided dosages to all the participants of various clinical trials. These dosages ranged between 200 to 400 mg daily but generally ranged between 100 to 200 mg.
There is some research that suggests that low doses that range between 50 to 100 mg are suitable for a number of neural issues. The optimal dosage range of the drug is not known and the dosages that have been mentioned here are based on the amount that had proven efficacy.
Summary: 7-Keto has a number of health benefits that are linked with its anti-aging, weight loss, and an improvement in immune health properties. No side effects of the drug have been reported in any of the clinical trials conducted to date.